10.03.2016, Lipid-based diets effectively combat Alzheimer's disease in mouse model

A Clinical Trial investigating the effects of Fortasyn Connect (Souvenaid) in Prodromal Alzheimer’s Disease:

Results of the LipiDiDiet study H. Soininen, P.J. Visser, M. Kivipelto, T. Hartmann for the LipiDiDiet study group (2016), presentation held at 14th International Athens/Springfield Symposium on Advances in Alzheimer Therapy, March 10, 2016

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01.05.2015, Vascular effects of oxysterols and oxyphytosterols in apoE -/- mice.

ATHEROSCLEROSIS, 2015 May; 240(1):73-9.

Oliver Weingärtner, Constanze Husche, Hans-Frieder Schött, Timo Speer, Michael Böhm, Charlotte M. Miller, Florence O. McCarthy, Jogchum Plat, Dieter Lütjohann, and Ulrich Laufs

In this study, we investigated the effects of oxidized cholesterol and oxidized sitosterol in mice. The major novel finding in this study is that the i.p. application of plant sterols or their oxidation products result in elevated plasma levels and increases sterol concentrations in the arterial wall. Interestingly, application of non-oxidized cholesterol or sitosterol increases their respective plasma concentrations but does not give rise to increased oxysterol or oxyphytosterol concentrations suggesting that endogenous oxidation does not play a major role in this context. Finally, only the elevation of 7β-OH-sitosterol resulted in increased ROS production in the arterial wall, but this did not affect endothelial cell quantification, endothelial cell migration, endothelial function, and early atherosclerotic lesion development.

>>> Click here for scientific abstract

22.04.2015, Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer's disease.

Brain Behav Immun. 2015 May;46:121-31.

Liu X, Hao W, Qin Y, Decker Y, Wang X, Burkart M, Schötz K, Menger MD, Fassbender K, Liu Y.

Inflammation in the brain is the main hallmark of Alzheimer’s disease (AD) and contributes to the disease pathogenesis. The extract from leaves of Ginkgo trees has been mixed with docosahexaenoic acid (DHA) an important omega-3 fatty acid and sold as a nutritional product for the prevention of AD. With this publication the LipiDiDiet researchers show how Ginkgo biloba extract reduces the inflammation in the AD brain.

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01.04.2015, Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia

Alzheimers Dement. 2015 Apr;11(4):434-443

Tolppanen AM, Solomon A, Kulmala J, Kareholt I, Ngandu T, Rusanen M, Laatikainen T, Soininen H, Kivipelto M.

The study investigated the associations between leisure-time physical activity from mid- to late life, the risk of dementia, and the role of body mass index, sex and APOE during 28-year follow-up. Moderate and low levels of midlife physical activity were associated with higher risk of dementia in comparison with the most active category. The benefits were more pronounced among men, overweight individuals, and APOE ε4 non-carriers. Maintaining high levels of physical activity or increasing physical activity after midlife was associated with lower dementia risk.

>>> Click here for scientific abstract

23.03.2015, Increased plant sterol deposition in vascular tissue characterizes patients with severe aortic stenosis and concomitant coronary artery disease.

STEROIDS [Epub ahead of print]

Alexandra Luister, Hans-Frieder Schött, Constanze Husche, Hans-Joachim Schäfers, Michael Böhm, Jogchum Plat, Stefan Gräber, Dieter Lütjohann, Ulrich Laufs, Oliver Weingärtner

This study consists of the data from with 104 patients suffering from severe aortic stenosis, treated with a consecutive aortic valve replacement. In plasma and valve cusp tissue of the patients the concentrations of phytosterols and oxyphytosterols were determined. Patients with concomitant CAD are characterized by increased deposition of plant sterols. Moreover, patients with concomitant CAD were characterized by increased oxyphytosterol concentrations in plasma and aortic valve cusps.

>>> Click here for scientific abstract

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